Sphingomyelin ability to act as chiral selector using nanodisc electrokinetic chromatography

Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography.

A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) technique has been developed for enantioseparation of vinpocetine using an inexpensive 2-hydroxypropyl-β-CD (HP-β-CD) as the chiral selector (CS). The best chiral separation was achieved using 40 mM HP-β-CD as the CS in 50 mM phosphate buffer (pH 7.0) consisting of 40 mM sodium dodecyl sulfate (SDS) at a separation tempera...

Coupling to chiral electrokinetic chromatography: Quenched phosphorescence detection of methotrexate

Enantioselective Extraction of Ofloxacin Enantiomers Using Ester Alcohol L-Tartarate as Chiral Selector

The distribution behavior of ofloxacin enantiomers was examined in the aqueous and organic solvent of a two-phase system containing chiral selector L-tartarate. The effect of extraction equilibrium time, buffer pH, organic solvents and length of alkyl chain of L-tartarate on the partition coefficients and enantioselectivity of racemic ofloxacin were investigated, respectively. The L-tartara...

Quenched phosphorescence as alternative detection mode in the chiral separation of methotrexate by electrokinetic chromatography

Quenched phosphorescence was used, for the first time, as detection mode in the chiral separation of methotrexate (MTX) enantiomers by electrokinetic chromatography. The detection is based on dynamic quenching of the strong emission of the phosphorophore 1-bromo-4-naphthalene sulfonic acid (BrNS) by MTX under deoxygenated conditions. The use of a background electrolyte with 3 mg/mL 2-hydroxypro...

enantioselective extraction of ofloxacin enantiomers using ester alcohol l-tartarate as chiral selector

the distribution behavior of ofloxacin enantiomers was examined in the aqueous and organic solvent of a two-phase system containing chiral selector l-tartarate. the effect of extraction equilibrium time, buffer ph, organic solvents and length of alkyl chain of l-tartarate on the partition coefficients and enantioselectivity of racemic ofloxacin were investigated, respectively. the l-tartarate f...